No, a Chihuahua and a Great Dane can’t naturally breed due to the physical size difference between the two dogs. They have never successfully bred these dogs.

They breed some designer dogs by artificial insemination. The breeders make it technically possible to breed drastically different-sized breeds. But they have never recorded a Chihuahua Great Dane mix.

Additionally, breeding with artificial insemination can be dangerous for the mother. That is if the father is of a much larger dog breed. Due to this, her puppies could grow too large for safe carrying and delivery.

Breeding a Chihuahua with a Great Dane using artificial insemination is only possible in theory, and shouldn’t be attempted due to these unknown factors that would put the mother’s life at risk.

Parody articles have imagined what a breeding and birth process would look like for a Chihuahua Great Dane mix, but none of the scenarios have been proven or tested.

Why Mix a Great Dane and Chihuahua?


Some people might want to breed the Chihuahua and the Great Dane to:

  • Create a dog mix with a reduced risk of pre-existing genetic diseases being inherited
  • Combine the Chihuahua’s loyalty with the Great Dane’s loving, gentle nature
  • Produce a unique-looking dog that stands out from all the other dog breeds
  • Enjoy the novelty of breeding the world’s biggest and smallest dogs

These advantages can be achieved in other dog mixes from different-sized dogs that are safe to breed, or by the parent breeds.

About the Great Dane

The Great Dane is a large, gentle dog with a friendly, reserved nature. Great Danes are good guard dogs, affectionate around children, and friendly with other animals in the home.

These dogs are known to be hostile around dogs they don’t know, and the breed is prone to health problems including bloat, heart disease, and cataracts.

About the Chihuahua

The Chihuahua is a tiny toy dog with a loyal, alert nature. Chihuahuas are terrier-like dogs that make good family watchdogs, require minimal exercise and have sassy personalities.

These dogs are known to bark excessively and are prone to health issues including luxating patellas, hip dysplasia, and eye problems.

Great Dane Chihuahua Alternatives

Attempting to breed Great Danes and Chihuahuas isn’t ethical because of the difference in size between the two dogs. There’s no evidence to suggest that professional breeders have successfully bred these dogs, likely due to the risk of genetic problems or issues during delivery.

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Breeding mixes with the Chihuahua Great Dane mix parent breeds can help to provide the appeal of this mix but avoid dangerous breeding practices.

Breed Mixes Combining Different-Sized Dogs

The following three breed mixes combine two different-sized dogs for a unique result:


The Pomsky is a cross between the medium-sized husky and the small Pomeranian. This dog has the body shape and thick, fluffy fur of the Pomeranian, mixed with the snout, ears, and gray-and-white markings of the husky.

Pomskies have fun-loving personalities and enjoy being the center of attention. Because they’re bred by the costly process of artificial insemination, the dogs are expensive — costing from $1,000 to $5,000.

German Shepherd Corgi

The German shepherd corgi combines the medium-to-large German shepherd with the small-to-medium Pembroke Welsh corgi. The dog mix’s body shape and size resemble the corgi, while the large ears, almond-shaped eyes, and long muzzle resemble the German shepherd.

This breed is a high-energy dog with an intelligent and strong-willed personality. The average cost of a German shepherd corgi puppy is $200 to $750.

Pitbull Daschund

The pitbull dachshund mix is a cross between the medium-sized American pitbull terrier and the small, short-legged dachshund. The dog inherits any combination of its parents’ traits and most commonly has the classic dachshund body shape with the head, nose, and muzzle of the pit bull.

Pitbull dachshunds are friendly, hyperactive dogs that unconditionally love their families, despite their stubborn, moody streak. Expect to pay between $400 and $600 for a pitbull dachshund mix.

Breed Mixes Including Great Danes or Chihuahuas

If you’re looking for a breed mix that includes Great Danes or Chihuahuas, the following two mixes may be suitable:

Great Dane German Shepherd

The Great Dane German shepherd mix, or Great shepherd, combines the large Great Dane with the medium-to-large German shepherd. The dog typically has the robust, tall body of a Great Dane, with the wide muzzle of a German shepherd.

Great Dane German shepherds enjoy living in big families and get along well with children. The dogs have a gentle, protective nature, and can be trained easily. The average cost of a Great shepherd puppy is $400 to $1,000.

Chihuahua Poodle

The Chihuahua poodle, or the chi-poo, is a cross between the tiny Chihuahua and a miniature poodle. The dog has the curly fur and floppy ears of a miniature poodle, and the round eyes and short snout of a Chihuahua.

Chihuahua poodle mixes are intelligent, playful, and independent dogs that have lots of energy to burn. The price of this dog breed is $500–$950 for a puppy.

Do Great Dane Chihuahua Mixes Exist?


Chihuahua Great Dane mixes don’t conclusively exist, and these dogs shouldn’t be bred due to ethical and medical concerns.

If you’re interested in a breed mix that combines a small dog with a medium-sized dog, consider the pomsky, the German shepherd corgi, and the pitbull dachshund.

More Chihuahua and Great Dane Mixes

Want a Chihuahua mix or Great Dane mix but aren’t keen on the ethical issues associated with the Chihuahua Great Dane mix? Check out these other hybrid dog breeds:

Chihuahua Mixes

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